Lewis x

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

Epitope information of EP0011

Epitope IDEP0011
Epitope nameLewis x
Structure
SequenceGal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R
AliasesLex,X-hapten,CD15
HistoryThe carbohydrate determinant having this terminal structure was described in glycolipids and milk oligosaccharides. It was also shown to comprise a part of murine developmental antigen .(see EP0042 Lewis x-i)[10][11]
DBPDB:1SL6 PDB:1UZ8 JCGGDB
Molecular weight529.5
Composition(Fuc)1(Gal)1(GlcNAc)1
Species

Homo sapiens
Mus musculus

Tissue and Cellular distribution

cancer cell
embryonic cell
epithelial cell
leukocyte
granulocyte
monocyte
milk(human)[37]

Subcellular distribution

Developmental change

Cell line

HL-60/human promyelocytic leukemia

Receptor

CD2[12]
DC-SIGN/DC-specific ICAM3-grabbing non-integrin[37]

Function

Involved in carbohydrate-carbohydrate interaction.Also implicated in apoptosis.[13*][21][14]
influence antigenic presentation and interfere with pathogen transfer in breastfed infants[37]

Diseases

acute leukemia[15][9][16*]
lymphoma[15][9][16*]

ApplicationUtilized as a marker for acute leukemia and lymphoma cells as CD15.[15][9][16*]
Comment