Sialyl 6-Sulfo Lewis x

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

Epitope information of EP0015

Epitope IDEP0015
Epitope nameSialyl 6-Sulfo Lewis x
Structure
SequenceNeu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-)-R
AliasesSialyl 6-Sulfo Lex,formerly 6-Sulfo Sialyl Lex
HistoryThe epitope was found to be a specific ligand for L-selectin present in high endothelial venules of human peripheral lymph nodes, and was shown to mediate homing of naive lymphocytes. [11]
The term Lewis refers to the family name of individuals suffering from a red blood cell incompatibility problem that helped lead to the discovery of this blood group.
DB
Molecular weight900.8
Composition(Fuc)1(Gal)1(GlcNAc)1(Neu5Ac)1(HSO3)1
Species

Tissue and Cellular distribution

high endothelial venule(human)
nonmalignant colonic epithelia[8]

Subcellular distribution

Developmental change

Cell line

Receptor

L-selectin(The hierarchy of binding strengths were 6-sulfo sialyl > sialyl = 6',6-bis-sulfo sialyl >> 6'-sulfo sialyl Lex.)[24]

Function

lymphocyte homing[18][17*][14]

Diseases

Application
Comment