Cyclic Sialyl 6-Sulfo Lewis x

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

Epitope information of EP0017

Epitope IDEP0017
Epitope nameCyclic Sialyl 6-Sulfo Lewis x
Structure
SequencecyclicNeu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc-R
AliasesCyclic Sialyl 6-Sulfo Lex
HistoryCyclic sialyl 6-sulfo Lex is efficiently formed by the action of the partly membranebound calcium-dependent enzyme, tentatively called "sialic acid cyclase," and a possible physiological significance of this reaction could be a rapid inactivation of selectin binding activity at the cell surface.[2]
DB
Molecular weight840.8
Composition(Fuc)1(Gal)1(GlcNAc)1(cyclicNeu5Ac)1(HSO3)1
Species

Homo sapiens

Tissue and Cellular distribution

colonic epithelia[1]
helper memory T cell
leukocyte[2]
memory B cell
monocyte
NK cell

Subcellular distribution

Developmental change

Cell line

ED40515/human adult T cell leukemia
U937/human leukemic monocyte lymphoma
YT/human NK-like leukemic

Receptor

Function

the accumulated intracellular cyclic sialyl 6-sulfo Lex determinant may unction as a dormant pool of selectin ligands[2][3]

Diseases

Application
Comment