MECA-79
| Antibody ID | AN0829 |
|---|
| Epitope ID | EP0025 |
|---|---|
| Epitope name | 6-Sulfo LacNAc Core1 |
| Recognition region | Gal(b1-4)[HSO3(-6)]GlcNAc(b1-3)Gal(b1-3)GalNAc-R |
| Immunoprecipitation | [1][5][7] |
| Immunoblot | [3][4][5][7][8][9] |
| ELISA/RIA | [10] |
| Flow cytometry | [4][9][11] |
| Histochemistry | [2][3][4][8][9][12][13][14][15] |
| Comment |
| Species | Rat |
|---|---|
| Category | Monoclonal |
| Isotype | IgM |
| Immunogen | mouse lymph node stromal cells |
| Availability | Biolegend |
| Applications |
| 1 | Hemmerich S, Butcher EC, Rosen SD. Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody. J Exp Med. 1994 Dec 1;180(6):2219-26 PMID: 7525849 |
|---|---|
| 2 | Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjö L, Sakuma K, Uchimura K, Khoo KH, Kannagi R, Rosen SD. KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar ;23:381-94 PMID: 23254996 |
| 3 | Yeh JC, Hiraoka N, Petryniak B, Nakayama J, Ellies LG, Rabuka D, Hindsgaul O, Marth JD, Lowe JB, Fukuda M. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. Cell. 2001 Jun 29;105:957-69 PMID: 11439191 |
| 4 | Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A, Imai Y, Ito Y, Fukuda M, Kawashima H. Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing. J Biol Chem. 2010 Dec 24;285:40864-78 PMID: 20929857 |
| 5 | Berg EL, Robinson MK, Warnock RA, Butcher EC. The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor. J Cell Biol. 1991 Jul ;114:343-9 PMID: 1712790 |
| 6 | Berg EL, McEvoy LM, Berlin C, Bargatze RF, Butcher EC. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature. 1993 Dec 16;366:695-8 PMID: 7505053 |
| 7 | Berg EL, McEvoy LM, Berlin C, Bargatze RF, Butcher EC. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature. 1993 Dec 16;366:695-8 PMID: 7505053 |
| 8 | Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D. Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope. Am J Pathol. 2002 May ;160:1669-81 PMID: 12000719 |
| 9 | Sinha RK, Yang G, Alexander C, Mage RG. De novo expression of MECA-79 glycoprotein-determinant on developing B lymphocytes in gut-associated lymphoid tissues. Immunology. 2006 Dec ;119:461-9 PMID: 17177829 |
| 10 | Bruehl RE, Bertozzi CR, Rosen SD. Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody. J Biol Chem. 2000 Oct 20;275:32642-8 PMID: 10938267 |
| 11 | Izawa D, Tanaka T, Saito K, Ogihara H, Usui T, Kawamoto S, Matsubara K, Okubo K, Miyasaka M. Expression profile of active genes in mouse lymph node high endothelial cells. Int Immunol. 1999 Dec ;11:1989-98 PMID: 10590265 |
| 12 | Streeter PR, Rouse BT, Butcher EC. Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J Cell Biol. 1988 Nov ;107:1853-62 PMID: 2460470 |
| 13 | Michie SA, Streeter PR, Bolt PA, Butcher EC, Picker LJ. The human peripheral lymph node vascular addressin. An inducible endothelial antigen involved in lymphocyte homing. Am J Pathol. 1993 Dec ;143:1688-98 PMID: 8256856 |
| 14 | Thomas SN, Rutkowski JM, Pasquier M, Kuan EL, Alitalo K, Randolph GJ, Swartz MA. Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage. J Immunol. 2012 Sep 1;189:2181-90 PMID: 22844119 |
| 15 | Noort AR, van Zoest KP, van Baarsen LG, Maracle CX, Helder B, Papazian N, Romera-Hernandez M, Tak PP, Cupedo T, Tas SW. Tertiary Lymphoid Structures in Rheumatoid Arthritis: NF-κB-Inducing Kinase-Positive Endothelial Cells as Central Players. Am J Pathol. 2015 Jul ;185:1935-43 PMID: 25963989 |