TKH2 / TKH-2
| Antibody ID | AN0365 |
|---|
| Epitope ID | EP0022 |
|---|---|
| Epitope name | Sialyl Tn Antigen |
| Recognition region | Neu5Ac(a2-6)GalNAc(a1-)Ser/Thr |
| Immunoprecipitation | |
| Immunoblot | [5][8] |
| ELISA/RIA | [6] |
| Flow cytometry | [8][12] |
| Histochemistry | [6][4][2][3][1][2][7][11][10][12][9][13] |
| Comment |
| Species | Mouse |
|---|---|
| Category | Monoclonal |
| Isotype | IgG |
| Immunogen | |
| Availability | |
| Applications |
| 1 | Nakagoe T, Nanashima A, Sawai T, Tuji T, Yamaguchi E, Jibiki M, Yamaguchi H, Yasutake T, Ayabe H, Matuo T, Tagawa Y. Different expression of sialyl Tn antigen between polypoid and nonpolypoid growth types of advanced colorectal carcinoma. Oncology. 2000 Aug ;59(2):131-8 PMID: 10971172 |
|---|---|
| 2 | Ogata S, Ho I, Chen A, Dubois D, Maklansky J, Singhal A, Hakomori S, Itzkowitz SH. Tumor-associated sialylated antigens are constitutively expressed in normal human colonic mucosa. Cancer Res. 1995 May 1;55(9):1869-74 PMID: 7537175 |
| 3 | Terasawa K, Furumoto H, Kamada M, Aono T. Expression of Tn and sialyl-Tn antigens in the neoplastic transformation of uterine cervical epithelial cells. Cancer Res. 1996 May 1;56(9):2229-32 PMID: 8616877 |
| 4 | Ikeda Y, Kuwano H, Baba K, Ikebe M, Matushima T, Adachi Y, Mori M, Sugimachi K. Expression of Sialyl-Tn antigens in normal squamous epithelium, dysplasia, and squamous cell carcinoma in the esophagus. Cancer Res. 1993 Apr 1;53(7):1706-8 PMID: 8453646 |
| 5 | Kudoh E, Komatu T, Nakaji S, Sugawara K, Kumae T. [Investigation of a new method for separation of neutrophils from a small volume of human blood] Nippon Eiseigaku Zasshi. 1992 Jun ;47(2):650-7 PMID: 1513058 |
| 6 | Kjeldsen T, Clausen H, Hirohashi S, Ogawa T, Iijima H, Hakomori S. Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res. 1988 Apr 15;48(8):2214-20 PMID: 2450649 |
| 7 | Wang F, Goto M, Kim YS, Higashi M, Imai K, Sato E, Yonezawa S. Altered GalNAc-alpha-2,6-sialylation compartments for mucin-associated sialyl-Tn antigen in colorectal adenoma and adenocarcinoma. J Histochem Cytochem. 2001 Dec ;49(12):1581-92 PMID: 11724906 |
| 8 | Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA. Biological significance of cancer-associated sialyl-Tn antigen: Modulation of malignant phenotype in gastric carcinoma cells. Cancer Lett. 2006 Sep 9;[Epub ahead of print]: PMID: 16965854 |
| 9 | Rajpert-De Meyts E, Poll SN, Goukasian I, Jeanneau C, Herlihy AS, Bennett EP, Skakkebaek NE, Clausen H, Giwercman A, Mandel U. Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation. Virchows Arch. 2007 Oct ;451(4):805-14 PMID: 17694322 |
| 10 | Yamashita Y, Chung YS, Sawada T, Horie R, Saito T, Murayama K, Kannagi R, Sowa M. F1 alpha: a novel mucin antigen associated with gastric carcinogenesis. Oncology. 1998 Jan ;55(1):70-6 PMID: 9428379 |
| 11 | Yamashita Y, Chung YS, Horie R, Kannagi R, Sowa M. Alterations in gastric mucin with malignant transformation: novel pathway for mucin synthesis. J Natl Cancer Inst. 1995 Mar 15;87(6):441-6 PMID: 7532228 |
| 12 | Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA. Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen. Cancer Res. 2004 Oct 1;64(19):7050-7 PMID: 15466199 |
| 13 | Conze T, Carvalho AS, Landegren U, Almeida R, Reis CA, David L, Söderberg O. MUC2 mucin is a major carrier of the cancer-associated sialyl-Tn antigen in intestinal metaplasia and gastric carcinomas. Glycobiology. 2010 Feb ;20(2):199-206 PMID: 19815850 |