2D3

Antibody IDAN0005
Epitope ID EP0008
Epitope nameSialyl Lewis a
Recognition regionNeu5Ac(a2-3)Gal(b1-3)GlcNAc(b1-)-R
Neu5Ac(a2-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-)-R
Immunoprecipitation
Immunoblot[3][1][2][5]
ELISA/RIA[5][4]
Flow cytometry
Histochemistry
Comment
Epitope ID EP0041
Epitope nameSialyl Lewis c
Recognition regionNeu5Ac(a2-3)Gal(b1-3)GlcNAc(b1-)-R
Neu5Ac(a2-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-)-R
Immunoprecipitation
Immunoblot[3][1][2][5]
ELISA/RIA[5][4]
Flow cytometry
Histochemistry
Comment
SpeciesMouse
CategoryMonoclonal
IsotypeIgM
ImmunogenCOLO 201/human colon adenocarcinoma
AvailabilityTokyo Chemical Industry Co., Ltd.
Applications
Up  Down
1 Takada A, Ohmori K, Yoneda T, Tsuyuoka K, Hasegawa A, Kiso M, Kannagi R.
Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium.
Cancer Res. 1993 Jan 15;53(2):354-61
PMID: 7678075
2 Iwai K, Ishikura H, Kaji M, Sugiura H, Ishizu A, Takahashi C, Kato H, Tanabe T, Yoshiki T.
Importance of E-selectin (ELAM-1) and sialyl Lewis(a) in the adhesion of pancreatic carcinoma cells to activated endothelium.
Int J Cancer. 1993 Jul 30;54(6):972-7
PMID: 7687590
3 Takada A, Ohmori K, Takahashi N, Tsuyuoka K, Yago A, Zenita K, Hasegawa A, Kannagi R.
Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A.
Biochem Biophys Res Commun. 1991 Sep 16;179(2):713-9
PMID: 1716885
4 Zenita K, Hirashima K, Shigeta K, Hiraiwa N, Takada A, Hashimoto K, Fujimoto E, Yago K, Kannagi R.
Northern hybridization analysis of VH gene expression in murine monoclonal antibodies directed to cancer-associated ganglioside antigens having various sialic acid linkages.
J Immunol. 1990 Jun 1;144(11):4442-51
PMID: 2111348
5 Kannagi R, Takada A, Shigeta K, Itai S, Hashimoto K.
[2D3 series, MSW 113 and other monoclonal antibodies directed to type 1 chain carbohydrate antigens]
Nippon Rinsho. 1990 Feb ;48 Suppl:992-8
PMID: 2355641