38.13

Antibody IDAN0212
Epitope ID EP0045
Epitope namePk Antigen
Recognition regionGal(a1-4)Gal(b1-4)Glc-R
Immunoprecipitation
Immunoblot[1][2*]
ELISA/RIA
Flow cytometry[3*]
Histochemistry[2*]
Comment
Epitope ID EP0071
Epitope nameGb3
Recognition regionGal(a1-4)Gal(b1-4)Glc-R
Immunoprecipitation
Immunoblot[1][2*]
ELISA/RIA
Flow cytometry[3*]
Histochemistry[2*]
Comment
SpeciesRat
CategoryMonoclonal
IsotypeIgM
Immunogen
AvailabilityBeckman Coulter
Santa Cruz Biotechnology, Inc.
AbD Serotec
abcam
Applications
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1 Cooling LL, Walker KE, Gille T, Koerner TA.
Shiga toxin binds human platelets via globotriaosylceramide (Pk antigen) and a novel platelet glycosphingolipid.
Infect Immun. 1998 Sep ;66(9):4355-66
PMID: 9712788
2 Okuda T, Tokuda N, Numata S, Ito M, Ohta M, Kawamura K, Wiels J, Urano T, Tajima O, Furukawa K, Furukawa K.
Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins.
J Biol Chem. 2006 Apr 14;281(15):10230-5
PMID: 16476743
3 Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.
J Biol Chem. 2000 May 19;275(20):15152-6
PMID: 10748143