| Epitope ID | EP0021 |
| Epitope name | Tn Antigen |
| Structure |  |
| Sequence | GalNAc(a1-)Ser/Thr |
| Aliases | |
| History | Mreau et al. found a T-like antigen expressed on the patient's red blood cells and named "Tn" (for T nouvell). Tn syndrome is characterized by panagglutinability,hemolytic anemia,leukopenia and thrombopenia due to expression of Tn antigen on blood cells and production of anti Tn antibody in the same individual. |
| DB | PDB:1N47
GlyTouCan:G57321FI
|
| Molecular weight | 221.2(Ser/Thr) |
| Composition | (GalNAc)1(Ser/Thr)1 |
| Species | Caenorhabditis elegans[65]
Drosophila melanogaster[57][75]
Echinococcus granulosus[17]
Fasciola hepatica[8][43]
Helminth parosites[43]
Herpes simplex virus typeI[64]
Homo sapiens
Macaca mulatta[15]
Mesocestoides corti[43]
Mesocestoides vogae[62]
Mus musculus
Nippostrongylus brasiliensis[43]
Taenia hydatigena[43]
Toxocara canis[43] |
| Tissue and Cellular distribution | cancer/breast[20][3][4][21][5][52][7][19]
cancer/breast(nipple aspirate fluid)[49][66]
cancer/colon(rat)(DMH induced)[55]
cancer/colon[19]
cancer/colorectal[1][18][19][35][40]
cancer/stomach[19][19]
cancer/liver[6][19]
cancer/ovary[11][7][19]
cancer/pancreas[9][10]
cancer/prostate[2]
cancer/cervical [12]
cancer/tubulopapillary carcinoma(dog)[67]
developing gut(fruit fly)[57]
HCC/primary hepatocellular carcinoma[90]
jurkat T leukemic cell[39]
lateral nerve cords (Mesocestoides vogae)[62]
normal epithelia/breast[77]
normal epithelia/colon[77]
normal epithelia/oral cavity [77]
retinal neuron(dog)[59]
retinal neuron(pig)[59]
retinal neuron(rat)[59]
salivery glands(fruit fly)[57]
spermatocyte[60]
spermatid[60]
spermatozoa[60]
stomach(monkey) [15]
testis[8]
tracheal system(fruit fly)[57]
tumor/mammary(mouse)[36]
T-lymphoid cell[22]
Tn erythrocyte[41][38]
Tn syndrome platelet[37]
epithelial cell/uterine cervical [12] |
| Subcellular distribution | thin rim at the cell membrane/supranuclear region of epitheolial cells[46]
Golgi Units(Drosophila)[75] |
| Developmental change | as early as nine weeks of gastation[46]
mouse central nervous tissue[23] |
| Cell line | Ab104A/highly aggressive fibrosarcoma[53]
HEK293/human embryonic kidney(transformed with EBNA-1 gene)[80]
Ishikawa cell[61]
Jurkat/human T cell lymphoblast-like[39][68*]
LMCR/rat colon adenocarcinoma[13]
LS180/human colon adenocarcinoma[40]
LSC/human colon cancer[51]
MCF-7/human breast adenocarcinoma[61][69][91]
TA3-Ha/mouse mammary adenocarcinoma[36][58][70] |
| Receptor | BPA/Bauhinia purpurea agglutinin[81]
CBL/Clarias batrachus lectin[82]
HPA/Helix pomatia agglutinin[93]
HPA/Helix pomatia agglutinin[83]
jacalin[84]
MGL/macrophage galactose-type lectin(human)[78]
MGL/macrophage galactose-type lectin[93][94]
MGL2/macrophage galactose-type lectin(mouse)[78]
MPA/Maclura pomifera[85]
Salvia bogotensis seed lectin[95]
SBA/soybean agglutinin[17652089 *]
SNA-II/Sambucus nigr lectin[100]
SRCL/scavenger receptor with C-type lectin/CL-P1/collectin placenta 1[80]
SSL/Salvia sclarea[96]
VML/Vatairea macrocarpa lectin[17652089 *]
VVA/Vicia villosa agglutinin[52]
VVA-B4/Veica villosa-B4[66][97][98]
winged bean basic agglutinin [99] |
| Function | lymphatic metastasis[71]
tube formation in Drosophila development[57]
modulation of malignant phenotype (gastric carcinoma cell) [56]
correlation with tumor stage, lymphatic invasion and lymph node matastasis [52] |
| Diseases | breast cancer[20][3][4][21][5][52][49]
cervical cancer[12]
colon cancer[51]
colorectal cancer[1][18][19][35]
fibrosarcoma[53]
gastric cancer[19]
liver cancer[6]
ovarian cancer[11]
pancreas cancer[9][10]
prostate cancer[2]
Tn syndorome[53][54][72][73][74]
Barrett's esophagus[63]
Schindler/Kanzaki desease (alpha-N acetylgalactosaminidase deficiency) [92] |
| Application | |
| Comment | |
