HNK-1

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

Epitope information of EP0001

Epitope IDEP0001
Epitope nameHNK-1
Structure
SequenceHSO3(-3)GlcA(b1-3)Gal(b1-4)GlcNAc-R
AliasesCD57,Leu-7
HistoryHNK-1 antibody was produced against a membrane antigen from cultured T cell line,HSB-2.[2]
DB JCGGDB
Molecular weight639.5
Composition(Gal)1(GlcA)1(GlcNAc)1(HSO3)1
Species

Calliphora vicina[4]
Canis familiaris[5]
Drosophila melanogaster[6*]
Gallus gallus[7]
Homo sapiens[2]
Mus musculus[8]
Rattus norvegicus[5]
Sus scrofa domesticus[5]

Tissue and Cellular distribution

brain
spinal cord[9*]
glial cell
natural killer cell[2]
neuron

Subcellular distribution

Developmental change

brain / postnatal[10]
immune system / postnatal
nervous system / embryo[11]

Cell line

P19/mouse teratocarcinoma(induced by retinoic acid)
SK-N-SH/human neuroblastoma

Receptor

amphoterin[12]
brevican[13]
L-selectin
laminin-1[14][15]
P-selectin[16]
SBP-1/SGGL-binding protein[17]

Function

learning and memory
neural crest cell migration[18]
neurite extension[19]
neuron-astrocyte adhesion[20]

Diseases

schizophrenia-like psychosis[21]
neuropathy [22][23]
exfoliation syndrome [51]
secondary cataract[24]

GlcA-P gene implicated as a cindidate for a schizophrenia-like psychosis.[21]
Some patients with neuropathy have IgM M-proteins that bind to miyelin and to MAG.[22][23]
The HNK-1 epitope may be of pathogenetic significance in some common and clinically important eye diseases, such as exfoliation syndrome and secondary cataract.[24]

Application
Comment