Lewis y

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

Epitope information of EP0018

Epitope IDEP0018
Epitope nameLewis y
Structure
SequenceFuc(a1-2)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R
AliasesLey,CD174, Y-hapten
HistoryLewis antigens and their derivatives such as Leb,Lex,sialyl Lex,sialyl Lea,and Ley were identified as tumor-associated structures approximately 20 years ago using hybridoma technology and showed that upregulation and/or de novo expression of these determinants on the tumor cell surface is associated with a poor prognosis.[5]
DBPDB:1S3K JCGGDB
Molecular weight675.6
Composition(Fuc)2(Gal)1(GlcNAc)1
Species

Homo sapiens

Tissue and Cellular distribution

cancer/ovary[2]
vascular endothelium
erythroid
granulocyte
hematopoietic progenitor cell
normal epithelia/breast[33]
normal epithelia/oral cavity[33]

Subcellular distribution

Developmental change

The Ley(CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes and CD34- cell lines.[3]

Cell line

KG1 (CD34+ leukemia cell line)[3]
KG1a (CD34+ leukemia cell line)[3]
TF1 (CD34+ leukemia cell line)[3]

Receptor

Function

The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[3]

Diseases

AIDS/acquired immune deficiency syndrome[4]
cholangiocarcinoma[6]
hepatocellular carcinoma[6]

Inappropriate tissue distribution of Ley blood-group antigens was observed in CCs(cholangiocarcinomas) and, much less frequently, in HCCs(hepatocellular carcinomas).[6]
Ley determinant is highly expressed in human immunodeficiency virus (HIV)-infected T cell lines and in CD3+ peripheral mature T cells of patients with acquired immune deficiency syndrome (AIDS) or with AIDS-related complex (ARC).[4]

ApplicationThe Lewis antigen is expression in pancreatic cancer cells and may be useful as a tumor marker.[7]
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