HNK-1

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

3 biosynthetic enzyme for EP0001

NameReaction
GlcAT-P,GlcAT-S Gal(b1-4)GlcNAc-R + UDP-GlcA = GlcA(b1-3)Gal(b1-4)GlcNAc-R + UDP
HNK-1 ST GlcA(b1-3)Gal(b1-4)GlcNAc-R + PAPS = HSO3(-3)GlcA(b1-3)Gal(b1-4)GlcNAc-R + PAP
NameGlcAT-P
ReactionGal(b1-4)GlcNAc-R + UDP-GlcA = GlcA(b1-3)Gal(b1-4)GlcNAc-R + UDP
Descriptionglucuronyltransferase P
ECEC 2.4.1.135
DBNCBI/Gene Swissprot/TrEMBL PDB CAZy:GT43
Gene deficient organisms[9*]
CommentGlcA-P gene implicated as a cindidate for a schizophrenia-like psychosis.[21]
NameGlcAT-S
ReactionGal(b1-4)GlcNAc-R + UDP-GlcA = GlcA(b1-3)Gal(b1-4)GlcNAc-R + UDP
Descriptionglucuronyltransferase S
ECEC 2.4.1.135
DBNCBI/Gene Swissprot/TrEMBL PDB CAZy:GT43
Gene deficient organisms
Comment
NameHNK-1 ST
ReactionGlcA(b1-3)Gal(b1-4)GlcNAc-R + PAPS = HSO3(-3)GlcA(b1-3)Gal(b1-4)GlcNAc-R + PAP
DescriptionHNK-1 sulfotransferase
ECEC 2.8.2.-
DBNCBI/Gene Swissprot/TrEMBL
Gene deficient organisms[46][47]
Comment

0 degradation enzyme for EP0001