6'-Sulfo Sialyl Lewis x

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

5 biosynthetic enzyme for EP0014

NameReaction
Beta4GalT GlcNAc(b1-)-R + UDP-Gal = Gal(b1-4)GlcNAc(b1-)-R + UDP
ST3Gal Gal(b1-4)GlcNAc(b1-)-R + CMP-Neu5Ac = Neu5Ac(a2-3)Gal(b1-4)GlcNAc(b1-)-R + CMP
FUT7 Neu5Ac(a2-3)Gal(b1-4)GlcNAc(b1-)-R + GDP-Fuc = Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R + GDP
GlcNAc6ST-1,HEC-GlcNAc6ST Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R + PAPS = Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R + PAP
NameBeta4GalT
ReactionGlcNAc(b1-)-R + UDP-Gal = Gal(b1-4)GlcNAc(b1-)-R + UDP
Descriptionbeta1,4-galactosyltransferase
ECEC 2.4.1.90
DBNCBI/Gene Swissprot/TrEMBL PDB CAZy:GT7
Gene deficient organisms
Comment
NameST3Gal
ReactionGal(b1-4)GlcNAc(b1-)-R + CMP-Neu5Ac = Neu5Ac(a2-3)Gal(b1-4)GlcNAc(b1-)-R + CMP
DescriptionGal beta(1-3/1-4)GlcNAc alpha2,3-Sialyltransferase
ECEC 2.4.99.-
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT29
Gene deficient organisms
Comment
NameFUT7
ReactionNeu5Ac(a2-3)Gal(b1-4)GlcNAc(b1-)-R + GDP-Fuc = Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R + GDP
Descriptionalpha-1,3-Fucosyltransferase / fucosyltransferase VII
ECEC 2.4.1.152
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT37
Gene deficient organisms
Comment
NameGlcNAc6ST-1
ReactionNeu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R + PAPS = Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R + PAP
DescriptionCHST2 / carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 2 / GST-2EC[10200296][9712885(http://www.jbc.org/cgi/reprint/273/35/22577)]
ECEC 2.8.2.-
DBNCBI/Gene Swissprot/TrEMBL
Gene deficient organisms[12*]
Comment
NameHEC-GlcNAc6ST
ReactionNeu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R + PAPS = Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R + PAP
DescriptionCHST4 / carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 / GST-3 / GlcNAc6ST-2 / LSST
ECEC 2.8.2.-
DBNCBI/Gene Swissprot/TrEMBL
Gene deficient organisms[21*][22][12*]
Comment

0 degradation enzyme for EP0014