Antibody IDAN0080
Epitope ID EP0021
Epitope nameTn Antigen
Recognition regionGalNAc(a1-)Ser/Thr
Flow cytometry[7]
CommentMLS128 binds to a carbohydrate epitope consisting of three consecutive Tn-antigens (GalNAcalpha-Ser/Thr). [8][7]
AvailabilityWako Pure Chemical Industries, Ltd.
ApplicationsA radiolabeled -Protein A binding assay to an IgG antibody bound on an antigen-coated plate[8]
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8 Nakada H, Inoue M, Numata Y, Tanaka N, Funakoshi I, Fukui S, Mellors A, Yamashina I.
Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128).
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2495-9
PMID: 7681597
2 Inoue M, Nakada H, Tanaka N, Yamashina I.
Tn antigen is expressed on leukosialin from T-lymphoid cells.
Cancer Res. 1994 Jan 1;54(1):85-8
PMID: 8261467
1 Nakada H, Inoue M, Tanaka N, Yamashina I.
Coexpression of cancer-associated carbohydrate antigens, Tn and sialyl Tn.
Glycoconj J. 1994 Jun ;11(3):262-5
PMID: 7841802
3 Ohshio G, Imamura T, Imamura M, Yamabe H, Sakahara H, Nakada H, Yamashina I.
Distribution of Tn antigen recognized by an anti-Tn monoclonal antibody (MLS128) in normal and malignant tissues of the digestive tract.
J Cancer Res Clin Oncol. 1995 ;121(4):247-52
PMID: 7751324
5 Freire T, Bay S, von Mensdorff-Pouilly S, Osinaga E.
Molecular basis of incomplete O-glycan synthesis in MCF-7 breast cancer cells: putative role of MUC6 in Tn antigen expression.
Cancer Res. 2005 Sep 1;65(17):7880-7
PMID: 16140958
6 Toda M, Akita K, Inoue M, Taketani S, Nakada H.
Down-modulation of B cell signal transduction by ligation of mucins to CD22.
Biochem Biophys Res Commun. 2008 Jul 18;372(1):45-50
PMID: 18474217
7 Morita N, Yajima Y, Asanuma H, Nakada H, Fujita-Yamaguchi Y.
Inhibition of cancer cell growth by anti-Tn monoclonal antibody MLS128.
Biosci Trends. 2009 Feb ;3(1):32-7
PMID: 20103942
4 Toda M, Hisano R, Yurugi H, Akita K, Maruyama K, Inoue M, Adachi T, Tsubata T, Nakada H.
Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells.
Biochem J. 2009 Feb 1;417(3):673-83
PMID: 18925876