Tn Antigen
General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference104 reference for EP0021
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1 | Itzkowitz SH, Yuan M, Montgomery CK, Kjeldsen T, Takahashi HK, Bigbee WL, Kim YS. Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer. Cancer Res. 1989 Jan 1;49(1):197-204 PMID: 2908846 |
2 | Zhang S, Zhang HS, Cordon-Cardo C, Reuter VE, Singhal AK, Lloyd KO, Livingston PO. Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens. Int J Cancer. 1997 Sep 26;73(1):50-6 PMID: 9334809 |
3 | Reed W, Bryne M, Clausen H, Dabelsteen E, Nesland JM. Simple mucins (T, sialosyl-T, Tn and sialosyl-Tn) are not diagnostic for malignant breast lesions. Anticancer Res. 1994 Mar ;14(2B):609-15 PMID: 7516636 |
4 | Imai J, Ghazizadeh M, Naito Z, Asano G. Immunohistochemical expression of T, Tn and sialyl-Tn antigens and clinical outcome in human breast carcinoma. Anticancer Res. 2001 Mar ;21(2B):1327-34 PMID: 11396208 |
5 | Wang BL, Springer GF, Kaufman MW. Concurrent immunohistochemical staining of tumor-infiltrating lymphocytes and carcinoma-associated T (Thomsen-Friedenreich)/Tn antigens in human breast carcinoma. J Histochem Cytochem. 1996 Feb ;44(2):187-91 PMID: 8609376 |
6 | Sasaki M, Yamato T, Nakanuma Y. Expression of sialyl-Tn, Tn and T antigens in primary liver cancer. Pathol Int. 1999 Apr ;49(4):325-31 PMID: 10365852 |
7 | Avichezer D, Springer GF, Schechter B, Arnon R. Immunoreactivities of polyclonal and monoclonal anti-T and anti-Tn antibodies with human carcinoma cells, grown in vitro and in a xenograft model. Int J Cancer. 1997 Jul 3;72(1):119-27 PMID: 9212232 |
8 | Freire T, Casaravilla C, Carmona C, Osinaga E. Mucin-type O-glycosylation in Fasciola hepatica: characterisation of carcinoma-associated Tn and sialyl-Tn antigens and evaluation of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity. Int J Parasitol. 2003 Jan ;33(1):47-56 PMID: 12547345 |
9 | Schuessler MH, Pintado S, Welt S, Real FX, Xu M, Melamed MR, Lloyd KO, Oettgen HF. Blood group and blood-group-related antigens in normal pancreas and pancreas cancer: enhanced expression of precursor type 1, Tn and sialyl-Tn in pancreas cancer. Int J Cancer. 1991 Jan 21;47(2):180-7 PMID: 1988363 |
10 | Terada T, Nakanuma Y. Expression of mucin carbohydrate antigens (T, Tn and sialyl Tn) and MUC-1 gene product in intraductal papillary-mucinous neoplasm of the pancreas. Am J Clin Pathol. 1996 May ;105(5):613-20 PMID: 8623771 |
11 | Ogawa H, Ghazizadeh M, Araki T. Tn and sialyl-Tn antigens as potential prognostic markers in human ovarian carcinoma. Gynecol Obstet Invest. 1996 ;41(4):278-83 PMID: 8793500 |
12 | Terasawa K, Furumoto H, Kamada M, Aono T. Expression of Tn and sialyl-Tn antigens in the neoplastic transformation of uterine cervical epithelial cells. Cancer Res. 1996 May 1;56(9):2229-32 PMID: 8616877 |
13 | Ogata S, Ho I, Maklansky J, Chen A, Werther JL, Reddish M, Longenecker BM, Sigurdson E, Iishi S, Zhang JY, Itzkowitz SH. A rat model to study the role of STn antigen in colon cancer. Glycoconj J. 2001 Nov ;18(11-12):871-82 PMID: 12820721 |
14 | Nakada H, Inoue M, Tanaka N, Yamashina I. Coexpression of cancer-associated carbohydrate antigens, Tn and sialyl Tn. Glycoconj J. 1994 Jun ;11(3):262-5 PMID: 7841802 |
15 | Linden S, Boren T, Dubois A, Carlstedt I. Rhesus monkey gastric mucins: oligomeric structure, glycoforms and Helicobacter pylori binding. Biochem J. 2004 May 1;379(Pt 3):765-75 PMID: 14736333 |
16 | Takano Y, Teranishi Y, Terashima S, Motoki R, Kawaguchi T. Lymph node metastasis-related carbohydrate epitopes of gastric cancer with submucosal invasion. Surg Today. 2000 ;30(12):1073-82 PMID: 11193738 |
17 | Alvarez Errico D, Medeiros A, Miguez M, Casaravilla C, Malgor R, Carmona C, Nieto A, Osinaga E. O-glycosylation in Echinococcus granulosus: identification and characterization of the carcinoma-associated Tn antigen. Exp Parasitol. 2001 Jun ;98(2):100-9 PMID: 11465993 |
18 | Yao Z, Sakahara H, Zhang M, Kobayashi H, Nakada H, Yamashina I, Konishi J. Radioimmunoimaging of colon cancer xenografts with anti-Tn monoclonal antibody. Nucl Med Biol. 1995 Feb ;22(2):199-203 PMID: 7767313 |
19 | Freire T, Medeiros A, Reis CA, Real FX, Osinaga E. Biochemical characterization of soluble Tn glycoproteins from malignant effusions of patients with carcinomas. Oncol Rep. 2003 Sep ;10(5):1577-85 PMID: 12883744 |
20 | Springer GF, Taylor CR, Howard DR, Tegtmeyer H, Desai PR, Murthy SM, Felder B, Scanlon EF. Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera. Cancer. 1985 Feb 1;55(3):561-9 PMID: 2981150 |
21 | Springer GF. Tn epitope (N-acetyl-D-galactosamine alpha-O-serine/threonine) density in primary breast carcinoma: a functional predictor of aggressiveness. Mol Immunol. 1989 Jan ;26(1):1-5 PMID: 2467192 |
22 | Inoue M, Nakada H, Tanaka N, Yamashina I. Tn antigen is expressed on leukosialin from T-lymphoid cells. Cancer Res. 1994 Jan 1;54(1):85-8 PMID: 8261467 |
23 | Akita K, Fushiki S, Fujimoto T, Inoue M, Oguri K, Okayama M, Yamashina I, Nakada H. Developmental expression of a unique carbohydrate antigen, Tn antigen, in mouse central nervous tissues. J Neurosci Res. 2001 Sep 15;65(6):595-603 PMID: 11550228 |
24 | Thurnher M, Clausen H, Sharon N, Berger EG. Use of O-glycosylation-defective human lymphoid cell lines and flow cytometry to delineate the specificity of Moluccella laevis lectin and monoclonal antibody 5F4 for the Tn antigen (GalNAc alpha 1-O-Ser/Thr). Immunol Lett. 1993 Jun ;36(3):239-43 PMID: 8370596 |
25 | Croce MV, Rabassa ME, Price MR, Segal-Eiras A. MUC1 mucin and carbohydrate associated antigens as tumor markers in head and neck squamous cell carcinoma. Pathol Oncol Res. 2001 ;7(4):284-91 PMID: 11882908 |
26 | Natali PG, Nicotra MR, Nuti M, Bigotti G, Calabro A, Schlom J, Giacomini P. Molecular profile, tissue distribution and prognostic evaluation of a human melanoma-carcinoma antigen recognized by the murine monoclonal antibody B1.1. Int J Biol Markers. 1988 Oct ;3(4):211-20 PMID: 3235849 |
27 | Takahashi HK, Metoki R, Hakomori S. Immunoglobulin G3 monoclonal antibody directed to Tn antigen (tumor-associated alpha-N-acetylgalactosaminyl epitope) that does not cross-react with blood group A antigen. Cancer Res. 1988 Aug 1;48(15):4361-7 PMID: 3390832 |
28 | Roxby DJ, Morley AA, Burpee M. Detection of the Tn antigen in leukaemia using monoclonal anti-Tn antibody and immunohistochemistry. Br J Haematol. 1987 Oct ;67(2):153-6 PMID: 3479188 |
29 | Roxby DJ, Pfeiffer MB, Morley AA, Kirkland MA. Expression of the Tn antigen in myelodysplasia, lymphoma, and leukemia. Transfusion. 1992 Nov ;32(9):834-8 PMID: 1471247 |
30 | Ohshio G, Imamura T, Imamura M, Yamabe H, Sakahara H, Nakada H, Yamashina I. Distribution of Tn antigen recognized by an anti-Tn monoclonal antibody (MLS128) in normal and malignant tissues of the digestive tract. J Cancer Res Clin Oncol. 1995 ;121(4):247-52 PMID: 7751324 |
31 | Hirohashi S, Clausen H, Yamada T, Shimosato Y, Hakomori S. Blood group A cross-reacting epitope defined by monoclonal antibodies NCC-LU-35 and -81 expressed in cancer of blood group O or B individuals: its identification as Tn antigen. Proc Natl Acad Sci U S A. 1985 Oct ;82(20):7039-43 PMID: 2413456 |
32 | Duk M, Steuden I, Dus D, Radzikowski C, Lisowska E. Application of chemically desialylated and degalactosylated human glycophorin for induction and characterization of anti-Tn monoclonal antibodies. Glycoconj J. 1992 Jun ;9(3):148-53 PMID: 1422133 |
33 | Grinstead JS, Koganty RR, Krantz MJ, Longenecker BM, Campbell AP. Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions. Biochemistry. 2002 Aug 6;41(31):9946-61 PMID: 12146959 |
34 | Kjeldsen T, Clausen H, Hirohashi S, Ogawa T, Iijima H, Hakomori S. Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res. 1988 Apr 15;48(8):2214-20 PMID: 2450649 |
35 | King MJ, Chan A, Roe R, Warren BF, Dell A, Morris HR, Bartolo DC, Durdey P, Corfield AP. Two different glycosyltransferase defects that result in GalNAc alpha-O-peptide (Tn) expression. Glycobiology. 1994 Jun ;4(3):267-79 PMID: 7949653 |
36 | Singhal A, Fohn M, Hakomori S. Induction of alpha-N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active immunotherapy in mice. Cancer Res. 1991 Mar 1;51(5):1406-11 PMID: 1997178 |
37 | Nurden AT, Dupuis D, Pidard D, Kieffer N, Kunicki TJ, Cartron JP. Surface modifications in the platelets of a patient with alpha-N-acetyl-D-galactosamine residues, the Tn-syndrome. J Clin Invest. 1982 Dec ;70(6):1281-91 PMID: 7174794 |
38 | Vainchenker W, Testa U, Deschamps JF, Henri A, Titeux M, Breton-Gorius J, Rochant H, Lee D, Cartron JP. Clonal expression of the Tn antigen in erythroid and granulocyte colonies and its application to determination of the clonality of the human megakaryocyte colony assay. J Clin Invest. 1982 May ;69(5):1081-91 PMID: 6175663 |
39 | Thurnher M, Wagner E, Clausen H, Mechtler K, Rusconi S, Dinter A, Birnstiel ML, Berger EG, Cotten M. Carbohydrate receptor-mediated gene transfer to human T leukaemic cells. Glycobiology. 1994 Aug ;4(4):429-35 PMID: 7827404 |
40 | Nakada H, Inoue M, Numata Y, Tanaka N, Funakoshi I, Fukui S, Yamashina I. Cancer-associated glycoproteins defined by a monoclonal antibody, MLS 128, recognizing the Tn antigen. Biochem Biophys Res Commun. 1992 Aug 31;187(1):217-24 PMID: 1520302 |
41 | Blumenfeld OO, Lalezari P, Khorshidi M, Puglia K, Fukuda M. O-linked oligosaccharides of glycophorins A and B in erythrocytes of two individuals with the Tn polyagglutinability syndrome. Blood. 1992 Nov 1;80(9):2388-95 PMID: 1421410 |
42 | Charpin C, Pancino G, Osinaga E, Bonnier P, Lavaut MN, Allasia C, Roseto A. Monoclonal antibody 83D4 immunoreactivity in human tissues: cellular distribution and microcytophotometric analysis of immunoprecipitates on tissue sections. Anticancer Res. 1992 Jan ;12(1):209-23 PMID: 1567169 |
43 | Casaravilla C, Freire T, Malgor R, Medeiros A, Osinaga E, Carmona C. Mucin-type O-glycosylation in helminth parasites from major taxonomic groups: evidence for widespread distribution of the Tn antigen (GalNAc-Ser/Thr) and identification of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity. J Parasitol. 2003 Aug ;89(4):709-14 PMID: 14533679 |
44 | Croce MV, Colussi AG, Price MR, Segal-Eiras A. Identification and characterization of different subpopulations in a human lung adenocarcinoma cell line (A549). Pathol Oncol Res. 1999 ;5(3):197-204 PMID: 10491017 |
45 | Jorgensen-Tye B, Levesque JP, Royle L, Doyonnas R, Chan JY, Dwek RA, Rudd PM, Harvey DJ, Simmons PJ, Watt SM. Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis. Tissue Antigens. 2005 Mar ;65(3):220-39 PMID: 15730515 |
46 | Wong ET, Lindall AW. Subcellular location of human parathyroid hormone immunoreactive peptides and preliminary evidence for a precursor to human PTH-1 (38545). Proc Soc Exp Biol Med. 1975 Feb ;148(2):387-92 PMID: 1121486 |
47 | King MJ, Parsons SF, Wu AM, Jones N. Immunochemical studies on the differential binding properties of two monoclonal antibodies reacting with Tn red cells. Transfusion. 1991 Feb ;31(2):142-9 PMID: 1847560 |
48 | Wua AM, Wub JH, Kuoa HW, Herpa A. Further characterization of the binding properties of two monoclonal antibodies recognizing human Tn red blood cells. J Biomed Sci. 2005 ;12(1):153-66 PMID: 15864747 |
49 | Kumar SR, Sauter ER, Quinn TP, Deutscher SL. Thomsen-Friedenreich and Tn antigens in nipple fluid: carbohydrate biomarkers for breast cancer detection. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6868-71 PMID: 16203776 |
50 | Giuffre G, Vitarelli E, Tuccari G, Barresi G. Immunohistochemical study of Tn, sialosyl-Tn and T antigens in human meningiomas. Eur J Histochem. 1998 ;42(3):197-203 PMID: 9857245 |
51 | Ragupathi G, Liu NX, Musselli C, Powell S, Lloyd K, Livingston PO. Antibodies against tumor cell glycolipids and proteins, but not mucins, mediate complement-dependent cytotoxicity. J Immunol. 2005 May 1;174(9):5706-12 PMID: 15843572 |
52 | Kawaguchi T, Takazawa H, Imai S, Morimoto J, Watanabe T, Kanno M, Igarashi S. Expression of Vicia villosa agglutinin (VVA)-binding glycoprotein in primary breast cancer cells in relation to lymphatic metastasis: is atypical MUC1 bearing Tn antigen a receptor of VVA? Breast Cancer Res Treat. 2006 Jul ;98(1):31-43 PMID: 16752227 |
53 | Schietinger A, Philip M, Yoshida BA, Azadi P, Liu H, Meredith SC, Schreiber H. A mutant chaperone converts a wild-type protein into a tumor-specific antigen. Science. 2006 Oct 13;314(5797):304-8 PMID: 17038624 |
54 | Ju T, Cummings RD. Protein glycosylation: chaperone mutation in Tn syndrome. Nature. 2005 Oct 27;437(7063):1252 PMID: 16251947 |
55 | Berriel E, Hill M, Barcia JJ, Ubillos L, Gonzalez M, Detjen G, Rondan M, Navarrete H, Osinaga E. Simple mucin-type cancer associated antigens are pre-cancerous biomarkers during 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Oncol Rep. 2005 Jul ;14(1):219-27 PMID: 15944793 |
56 | Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA. Biological significance of cancer-associated sialyl-Tn antigen: Modulation of malignant phenotype in gastric carcinoma cells. Cancer Lett. 2006 Sep 9;[Epub ahead of print]: PMID: 16965854 |
57 | Tian E, Ten Hagen KG. O-linked glycan expression during Drosophila development. Glycobiology. 2007 Aug ;17(8):820-7 PMID: 17522109 |
58 | Toda M, Hisano R, Yurugi H, Akita K, Maruyama K, Inoue M, Adachi T, Tsubata T, Nakada H. Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells. Biochem J. 2009 Feb 1;417(3):673-83 PMID: 18925876 |
59 | Wu WC, Lai CC, Liu JH, Singh T, Li LM, Peumans WJ, Van Damme EJ, Wu AM. Differential binding to glycotopes among the layers of three mammalian retinal neurons by man-containing N-linked glycan, T(alpha) (Galbeta1-3GalNAcalpha1-), Tn (GalNAcalpha1-Ser/Thr) and I (beta)/II (beta) (Galbeta1-3/4GlcNAcbeta-) reactive lectins. Neurochem Res. 2006 May ;31(5):619-28 PMID: 16770733 |
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82 | Singha B, Adhya M, Chatterjee BP. Catfish (Clarias batrachus) serum lectin recognizes polyvalent Tn [alpha-D-GalpNAc1-Ser/Thr], Talpha [beta-D-Galp-(1-->3)-alpha-D-GalpNAc1-Ser/Thr], and II [beta-D-Galp(1-->4)-beta-D-GlcpNAc1-] mammalian glycotopes. Carbohydr Res. 2008 Sep 22;343(14):2384-92 PMID: 18662810 |
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91 | Danussi C, Coslovi A, Campa C, Mucignat MT, Spessotto P, Uggeri F, Paoletti S, Colombatti A. A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction. Glycobiology. 2009 Oct ;19(10):1056-67 PMID: 19528665 |
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95 | Vega N, Pérez G. Isolation and characterisation of a Salvia bogotensis seed lectin specific for the Tn antigen. Phytochemistry. 2006 Feb ;67(4):347-55 PMID: 16413042 |
96 | Wu AM. Lectinochemical studies on the glyco-recognition factors of a Tn (GalNAcalpha1-->Ser/Thr) specific lectin isolated from the seeds of Salvia sclarea. J Biomed Sci. 2005 ;12(1):167-84 PMID: 15864748 |
97 | Manimala JC, Li Z, Jain A, VedBrat S, Gildersleeve JC. Carbohydrate array analysis of anti-Tn antibodies and lectins reveals unexpected specificities: implications for diagnostic and vaccine development. Chembiochem. 2005 Dec ;6(12):2229-41 PMID: 16252298 |
98 | Kaszowska M, Norgren AS, Arvidson PI, Sandström C. Studies on the interactions between glycosylated beta3-peptides and the lectin Vicia villosa by saturation transfer difference NMR spectroscopy. Carbohydr Res. 2009 Dec 14;344(18):2577-80 PMID: 19863951 |
99 | Kulkarni KA, Sinha S, Katiyar S, Surolia A, Vijayan M, Suguna K. Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: a crystallographic, thermodynamic and modelling study. FEBS Lett. 2005 Dec 19;579(30):6775-80 PMID: 16310781 |
100 | Maveyraud L, Niwa H, Guillet V, Svergun DI, Konarev PV, Palmer RA, Peumans WJ, Rougé P, Van Damme EJ, Reynolds CD, Mourey L. Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra. Proteins. 2009 Apr ;75(1):89-103 PMID: 18798567 |
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