GlycoEpitope: show

Disialyl Lewis a

Epitope information of EP0040

Epitope ID	EP0040
Epitope name	Disialyl Lewis a
Structure
Sequence	Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-6)][Fuc(a1-4)]GlcNAc(b1-)-R
Aliases	Disialyl Le^a,Disialosyl Le^a, 2-3,2-6 disialyl Le^a
History	A new fucoganglioside, disialosyl Le^a, has been found in the disialoganglioside fraction of human colonic adenocarcinoma.[1 *]
DB	GlyTouCan:G93400AK JCGGDB
Molecular weight	1274.2
Composition	(Fuc)1(Gal)2(GlcNAc)1(Neu5Ac)2
Species	Homo sapiens
Tissue and Cellular distribution	nonmalignant epithelial cell/digestive organs bronchial tube[4] prostate gland
Subcellular distribution
Developmental change	The transcription of a gene encoding the alpha 2-6 sialyltransferase was markedly down-regulated in cancer cells compared with nonmalignant epithelial cells,which is in line with the decreased expression of disialyl Le^a and increased expression of sialyl Le^a in cancers.[2]
Cell line	DLD-1/human colon adenocarcinoma HT-29/human colon adenocarcinoma Lovo/human colon adenocarcinoma SW1116/human colon carcinoma[3 *]
Receptor	Siglec-7 / Immunoglobulin-Like Lectin-7[2][5]
Function	The 2-3,2-6 disialyl Le^a determinant on epithelial cells may play a role in protecting normal epithelial cells.[2]
Diseases	Mucin antigen carrying 2-3 sialylated Le^a antigen or 2-3, 2-6 disialylated Lc4 antigen in cancer patients had the lowest carbohydrate/protein ratio. Thus, the carbohydrate/protein ratio in the type 1 chain mucin antigens in sera of normal subjects is higher than that in sera of cancer patients.[6]
Application	The resulting ratio of serum 2-3/2-6 sialylated Le^a antigens was frequently high in patients with malignancy and was low in patients with benign disorders of these digestive organs. Therefore,the 2-3/2-6 sialylated Le^a antigen ratio is a useful for the differential diagnosis of malignant disorders in these organs.[7]
Comment

Epitope ID

EP0040

Epitope name

Disialyl Lewis a

Structure

Sequence

Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-6)][Fuc(a1-4)]GlcNAc(b1-)-R

Aliases

Disialyl Le^a,Disialosyl Le^a, 2-3,2-6 disialyl Le^a

History

A new fucoganglioside, disialosyl Le^a, has been found in the disialoganglioside fraction of human colonic adenocarcinoma.[1 *]

GlyTouCan:G93400AK JCGGDB

Molecular weight

1274.2

Composition

(Fuc)1(Gal)2(GlcNAc)1(Neu5Ac)2

Species

Homo sapiens

Tissue and Cellular distribution

nonmalignant epithelial cell/digestive organs
bronchial tube[4]
prostate gland

Subcellular distribution

Developmental change

The transcription of a gene encoding the alpha 2-6 sialyltransferase was markedly down-regulated in cancer cells compared with nonmalignant epithelial cells,which is in line with the decreased expression of disialyl Le^a and increased expression of sialyl Le^a in cancers.[2]

Cell line

DLD-1/human colon adenocarcinoma
HT-29/human colon adenocarcinoma
Lovo/human colon adenocarcinoma
SW1116/human colon carcinoma[3 *]

Receptor

Siglec-7 / Immunoglobulin-Like Lectin-7[2][5]

Function

The 2-3,2-6 disialyl Le^a determinant on epithelial cells may play a role in protecting normal epithelial cells.[2]

Diseases

Mucin antigen carrying 2-3 sialylated Le^a antigen or 2-3, 2-6 disialylated Lc4 antigen in cancer patients had the lowest carbohydrate/protein ratio. Thus, the carbohydrate/protein ratio in the type 1 chain mucin antigens in sera of normal subjects is higher than that in sera of cancer patients.[6]

Application

The resulting ratio of serum 2-3/2-6 sialylated Le^a antigens was frequently high in patients with malignancy and was low in patients with benign disorders of these digestive organs. Therefore,the 2-3/2-6 sialylated Le^a antigen ratio is a useful for the differential diagnosis of malignant disorders in these organs.[7]

Comment