O-Fucose Glycan /EGF Repeat

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

5 biosynthetic enzyme for EP0005

NameReaction
O-FucT-1 Ser/Thr + GDP-Fuc = Fuc(a1-)Ser/Thr + GDP
Beta3GlcNAcT Fuc(a1-)Ser/Thr + UDP-GlcNAc = GlcNAc(b1-3)Fuc(a1-)Ser/Thr + UDP
Beta4GalT GlcNAc(b1-3)Fuc(a1-)Ser/Thr + UDP-Gal = Gal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr+ UDP
ST3Gal III Gal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr + CMP-Neu5Ac = Neu5Ac(a2-3)Gal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr
ST6Gal I Gal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr + CMP-Neu5Ac = Neu5Ac(a2-6)Gal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr
NameO-FucT-1
ReactionSer/Thr + GDP-Fuc = Fuc(a1-)Ser/Thr + GDP
DescriptionO-fucosyltransferase 1/peptide-O-fucosyltransferase/GDP-Fuc: protein O-fucosyltransferase
ECEC 2.4.1.221
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT65
Gene deficient organisms
Comment
NameBeta3GlcNAcT
ReactionFuc(a1-)Ser/Thr + UDP-GlcNAc = GlcNAc(b1-3)Fuc(a1-)Ser/Thr + UDP
DescriptionO-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase/Fringe
ECEC 2.4.1.222
DBNCBI/Gene Swissprot/TrEMBL
Gene deficient organisms
Comment
NameBeta4GalT
ReactionGlcNAc(b1-3)Fuc(a1-)Ser/Thr + UDP-Gal = Gal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr+ UDP
DescriptionUDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1/Beta-1,4-galactosyltransferase 1
ECEC 2.4.1.38
DBNCBI/Gene Swissprot/TrEMBL PDB CAZy:GT7
Gene deficient organisms
Comment
NameST3Gal III
ReactionGal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr + CMP-Neu5Ac = Neu5Ac(a2-3)Gal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr
DescriptionCMP-NeuAc : Galbeta1,3GlcNAc alpha2,3-sialyltransferase
ECEC 2.4.99.6
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT29
Gene deficient organisms
Comment
NameST6Gal I
ReactionGal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr + CMP-Neu5Ac = Neu5Ac(a2-6)Gal(b1-4)GlcNAc(b1-3)Fuc(a1-)Ser/Thr
DescriptionCMP-NeuAc : Galbeta1,4GlcNAc alpha2,6-sialyltransferase
ECEC 2.4.99.1
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT29
Gene deficient organisms
Comment

0 degradation enzyme for EP0005