Antibody IDAN0169
Epitope ID EP0009
Epitope name3'-Sulfo Lewis a
Recognition regionHSO3(-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal-R
Flow cytometry
Immunogensulfomucin from human colonie mucosa[6]
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1 Tsuiji H, Nakatsugawa S, Ishigaki T, Irimura T.
Malignant and other properties of human colon carcinoma cells after suppression of sulfomucin production in vitro.
Clin Exp Metastasis. 1999 Mar ;17(2):97-104
PMID: 10411100
2 Loveless RW, Yuen CT, Tsuiji H, Irimura T, Feizi T.
Monoclonal antibody 91.9H raised against sulfated mucins is specific for the 3'-sulfated Lewisa tetrasaccharide sequence.
Glycobiology. 1998 Dec ;8(12):1237-42
PMID: 9858646
3 Tsuiji H, Hong JC, Kim YS, Ikehara Y, Narimatsu H, Irimura T.
Novel carbohydrate specificity of monoclonal antibody 91.9H prepared against human colonic sulfomucin: recognition of sulfo-Lewis(a) structure.
Biochem Biophys Res Commun. 1998 Dec 18;253(2):374-81
PMID: 9878545
4 Ikeda N, Eguchi H, Nishihara S, Narimatsu H, Kannagi R, Irimura T, Ohta M, Matsuda H, Taniguchi N, Honke K.
A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes.
J Biol Chem. 2001 Oct 19;276(42):38588-94
PMID: 11504739
5 Bodger K, Campbell F, Rhodes JM.
Detection of sulfated glycoproteins in intestinal metaplasia: a comparison of traditional mucin staining with immunohistochemistry for the sulfo-Lewis(a) carbohydrate epitope.
J Clin Pathol. 2003 Sep ;56(9):703-8
PMID: 12944557
6 Yamori T, Ota DM, Cleary KR, Hoff S, Hager LG, Irimura T.
Monoclonal antibody against human colonic sulfomucin: immunochemical detection of its binding sites in colonic mucosa, colorectal primary carcinoma, and metastases.
Cancer Res. 1989 Feb 15;49(4):887-94
PMID: 2912559