Poly-N-Acetylneuraminic Acid
General | Antibody | Glycoprotein | Glycolipid | Enzyme | ReferenceEpitope information of EP0101
| Epitope ID | EP0101 |
|---|---|
| Epitope name | Poly-N-Acetylneuraminic Acid |
| Structure |  |
| Sequence | (Neu5Ac) n |
| Aliases | Polysialic acid |
| History | Membranous sialyltransferase complexes from Escherichia coli K-235 catalyze the synthesis of surface polymers containing alpha-2,8-ketosidically linked polysialic acid.[7*] |
| DB | GlyTouCan:G80631ZD |
| Molecular weight | |
| Composition | (Neu5Acn)1 |
| Species | |
| Tissue and Cellular distribution | cancer cell |
| Subcellular distribution | |
| Developmental change | |
| Cell line | CHP-134/human neuroblastoma |
| Receptor | |
| Function | Polysialic acid chains on neural cell adhesion molecule (NCAM) present this homotypic interaction, are anti-adhesive and change shape. Cell migration and axon development during brain development are thus associated with polysialation of NCAM.[8] |
| Diseases | neuroblastoma |
| Application | |
| Comment |