GL7

Antibody IDAN0826
Epitope ID EP0147
Epitope name2-6 Sialyl LacNAc
Recognition regionNeu5Ac(a2-6)Gal(b1-4)GlcNAc(b1-)-R
Immunoprecipitation
Immunoblot[2]
ELISA/RIA[1][2]
Flow cytometry[1][2][3]
Histochemistry[2][4]
Comment
SpeciesRat
CategoryMonoclonal
IsotypeIgM
Immunogen
AvailabilityeBioscience
Applications
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1 Kimura N, Ohmori K, Miyazaki K, Izawa M, Matsuzaki Y, Yasuda Y, Takematsu H, Kozutsumi Y, Moriyama A, Kannagi R.
Human B-lymphocytes express alpha2-6-sialylated 6-sulfo-N-acetyllactosamine serving as a preferred ligand for CD22/Siglec-2.
J Biol Chem. 2007 Nov 2;282:32200-7
PMID: 17728258
2 Naito Y, Takematsu H, Koyama S, Miyake S, Yamamoto H, Fujinawa R, Sugai M, Okuno Y, Tsujimoto G, Yamaji T, Hashimoto Y, Itohara S, Kawasaki T, Suzuki A, Kozutsumi Y.
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation.
Mol Cell Biol. 2007 Apr ;27:3008-22
PMID: 17296732
3 Kannagi R, Ohmori K, Kimura N.
Anti-oligosaccharide antibodies as tools for studying sulfated sialoglycoconjugate ligands for siglecs and selectins.
Glycoconj J. 2009 Nov ;26:923-8
PMID: 18347975
4 Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjö L, Sakuma K, Uchimura K, Khoo KH, Kannagi R, Rosen SD.
KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing.
Glycobiology. 2013 Mar ;23:381-94
PMID: 23254996