O-Mannosyl Glycan / Mammalian

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

Epitope information of EP0002

Epitope IDEP0002
Epitope nameO-Mannosyl Glycan / Mammalian
Structure
SequenceNeu5Ac(a2-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-)Ser/Thr
Aliases
History
DB GlyTouCan:G59126YU
Molecular weight836.8(Ser/Thr)
Composition(Gal)1(GlcNAc)1(Man)1(Neu5Ac)1(Ser/Thr)1
Species

Bos taurus[2*]
Homo sapiens
Mus musculus
Oryctolagus cuniculus[1][3][2]
Ovis aries[4*]
Tissue and Cellular distribution

brain
muscle
fibroblast
myoblast
Subcellular distribution
Developmental change
Cell line
Receptor

laminin-2
Function
Diseases

MEB/muscle-eye-brain disease[6]
WWS/walker-warburg syndrome [6]
muscular dystrophy [7]
neuronal migration disorder [7]

Muscle-Eye-Brain disease (MEB) and Walker-Warburg Syndrome (WWS) have mutations in genes encoding glycosyltransferases needed for O -mannosyl oligosaccharide synthesis.[6]
Muscular dystrophy and neuronal migration disorder are caused by mutations in a glycosyltransferase, POMGnT1.[7]
Application
Comment