O-Mannosyl Glycan / Mammalian

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

4 biosynthetic enzyme for EP0002

NameReaction
POMT1,POMT2 Ser/Thr + Dol-P-Man = Man(a1-)Ser/Thr + Dol-P
POMGnT1 Man(a1-)Ser/Thr + UDP-GlcNAc = GlcNAc(b1-2)Man(a1-)Ser/Thr + UDP
GalT GlcNAc(b1-2)Man(a1-)Ser/Thr + UDP-Gal = Gal(b1-4)GlcNAc(b1-2)Man(a1-)Ser/Thr + UDP
NamePOMT1
ReactionSer/Thr + Dol-P-Man = Man(a1-)Ser/Thr + Dol-P
DescriptionO-mannosyltransferase 1
ECEC 2.4.1.109
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT39
Gene deficient organisms
Comment
NamePOMT2
ReactionSer/Thr + Dol-P-Man = Man(a1-)Ser/Thr + Dol-P
DescriptionO-mannosyltransferase 2
ECEC 2.4.1.109
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT39
Gene deficient organisms
Comment
NamePOMGnT1
ReactionMan(a1-)Ser/Thr + UDP-GlcNAc = GlcNAc(b1-2)Man(a1-)Ser/Thr + UDP
Descriptionprotein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase
ECEC 2.4.1.-
DBNCBI/Gene Swissprot/TrEMBL
Gene deficient organisms
CommentMuscular dystrophy and neuronal migration disorder are caused by mutations in a glycosyltransferase, POMGnT1.[7]
NameGalT
ReactionGlcNAc(b1-2)Man(a1-)Ser/Thr + UDP-Gal = Gal(b1-4)GlcNAc(b1-2)Man(a1-)Ser/Thr + UDP
Description
EC
DBNCBI/Gene Swissprot/TrEMBL
Gene deficient organisms
Comment

0 degradation enzyme for EP0002