T Antigen
General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference77 reference for EP0020
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| 1 | Itzkowitz SH, Yuan M, Montgomery CK, Kjeldsen T, Takahashi HK, Bigbee WL, Kim YS. Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer. Cancer Res. 1989 Jan 1;49(1):197-204 PMID: 2908846 |
2 | Orntoft TF, Mors NP, Eriksen G, Jacobsen NO, Poulsen HS. Comparative immunoperoxidase demonstration of T-antigens in human colorectal carcinomas and morphologically abnormal mucosa. Cancer Res. 1985 Jan ;45(1):447-52 PMID: 3880667 |
3 | Yuan M, Itzkowitz SH, Boland CR, Kim YD, Tomita JT, Palekar A, Bennington JL, Trump BF, Kim YS. Comparison of T-antigen expression in normal, premalignant, and malignant human colonic tissue using lectin and antibody immunohistochemistry. Cancer Res. 1986 Sep ;46(9):4841-7 PMID: 3731131 |
4 | Cao Y, Karsten UR, Liebrich W, Haensch W, Springer GF, Schlag PM. Expression of Thomsen-Friedenreich-related antigens in primary and metastatic colorectal carcinomas. A reevaluation. Cancer. 1995 Nov 15;76(10):1700-8 PMID: 8625037 |
5 | Sata T, Roth J, Zuber C, Stamm B, Rinderle SJ, Goldstein IJ, Heitz PU. Studies on the Thomsen-Friedenreich antigen in human colon with the lectin Amaranthin. Normal and neoplastic epithelium express only cryptic T antigen. Lab Invest. 1992 Feb ;66(2):175-86 PMID: 1370965 |
6 | Zhang S, Zhang HS, Cordon-Cardo C, Reuter VE, Singhal AK, Lloyd KO, Livingston PO. Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens. Int J Cancer. 1997 Sep 26;73(1):50-6 PMID: 9334809 |
7 | Desai PR, Ujjainwala LH, Carlstedt SC, Springer GF. Anti-Thomsen-Friedenreich (T) antibody-based ELISA and its application to human breast carcinoma detection. J Immunol Methods. 1995 Dec 27;188(2):175-85 PMID: 8551046 |
8 | Reed W, Bryne M, Clausen H, Dabelsteen E, Nesland JM. Simple mucins (T, sialosyl-T, Tn and sialosyl-Tn) are not diagnostic for malignant breast lesions. Anticancer Res. 1994 Mar ;14(2B):609-15 PMID: 7516636 |
9 | Imai J, Ghazizadeh M, Naito Z, Asano G. Immunohistochemical expression of T, Tn and sialyl-Tn antigens and clinical outcome in human breast carcinoma. Anticancer Res. 2001 Mar ;21(2B):1327-34 PMID: 11396208 |
10 | Wang BL, Springer GF, Kaufman MW. Concurrent immunohistochemical staining of tumor-infiltrating lymphocytes and carcinoma-associated T (Thomsen-Friedenreich)/Tn antigens in human breast carcinoma. J Histochem Cytochem. 1996 Feb ;44(2):187-91 PMID: 8609376 |
11 | Sasaki M, Yamato T, Nakanuma Y. Expression of sialyl-Tn, Tn and T antigens in primary liver cancer. Pathol Int. 1999 Apr ;49(4):325-31 PMID: 10365852 |
12 | Flucke U, Zirbes TK, Schroder W, Monig SP, Koch V, Schmitz K, Thiele J, Dienes HP, Holscher AH, Baldus SE. Expression of mucin-associated carbohydrate core antigens in esophageal squamous cell carcinomas. Anticancer Res. 2001 May ;21(3C):2189-93 PMID: 11501845 |
13 | Langkilde NC, Wolf H, Clausen H, Orntoft TF. Human urinary bladder carcinoma glycoconjugates expressing T-(Gal beta(1-3)GalNAc alpha 1-O-R) and T-like antigens: a comparative study using peanut agglutinin and poly- and monoclonal antibodies. Cancer Res. 1992 Sep 15;52(18):5030-6 PMID: 1516058 |
14 | Wolf MF, Schmitt HR, Schumacher K. Expression of Thomsen-Friedenreich (TF) antigens on lymphocytes. I. Distribution of cryptic and exposed TF antigens on murine lymphocytes from different lymphoid organs: detection with an anti-TF monoclonal antibody and peanut agglutinin. Cell Immunol. 1989 Jul ;121(2):360-5 PMID: 2736629 |
15 | Singh R, Campbell BJ, Yu LG, Fernig DG, Milton JD, Goodlad RA, FitzGerald AJ, Rhodes JM. Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44. Glycobiology. 2001 Jul ;11(7):587-92 PMID: 11447138 |
16 | Avichezer D, Springer GF, Schechter B, Arnon R. Immunoreactivities of polyclonal and monoclonal anti-T and anti-Tn antibodies with human carcinoma cells, grown in vitro and in a xenograft model. Int J Cancer. 1997 Jul 3;72(1):119-27 PMID: 9212232 |
17 | Nakada H, Inoue M, Tanaka N, Wakamiya N, Yamashina I. Expression of the T antigen on a T-lymphoid cell line, supT1. Glycoconj J. 1995 Jun ;12(3):356-9 PMID: 7496150 |
18 | Sata T, Zuber C, Rinderle SJ, Goldstein IJ, Roth J. Expression patterns of the T antigen and the cryptic T antigen in rat fetuses: detection with the lectin amaranthin. J Histochem Cytochem. 1990 Jun ;38(6):763-74 PMID: 2335739 |
19 | Glinsky VV, Glinsky GV, Rittenhouse-Olson K, Huflejt ME, Glinskii OV, Deutscher SL, Quinn TP. The role of Thomsen-Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium. Cancer Res. 2001 Jun 15;61(12):4851-7 PMID: 11406562 |
20 | Linden S, Boren T, Dubois A, Carlstedt I. Rhesus monkey gastric mucins: oligomeric structure, glycoforms and Helicobacter pylori binding. Biochem J. 2004 May 1;379(Pt 3):765-75 PMID: 14736333 |
21 | Nagata Y, Abe M, Kobayashi K, Yoshida K, Ishibashi T, Naoe T, Nakayama E, Shiku H. Glycine to aspartic acid mutations at codon 13 of the c-Ki-ras gene in human gastrointestinal cancers. Cancer Res. 1990 Feb 1;50(3):480-2 PMID: 2404571 |
22 | Yu LG, Jansson B, Fernig DG, Milton JD, Smith JA, Gerasimenko OV, Jones M, Rhodes JM. Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta1-3 N-acetyl-galactosamine). Int J Cancer. 1997 Nov 4;73(3):424-31 PMID: 9359491 |
23 | Takano Y, Teranishi Y, Terashima S, Motoki R, Kawaguchi T. Lymph node metastasis-related carbohydrate epitopes of gastric cancer with submucosal invasion. Surg Today. 2000 ;30(12):1073-82 PMID: 11193738 |
24 | RULE L. [The new ophthalmologic hospital in Djeddah (Arabia)] Arch Hosp (Paris). 1952 May ;7(80):33 PMID: 12995288 |
25 | Hanisch FG, Stadie T, Bosslet K. Monoclonal antibody BW835 defines a site-specific Thomsen-Friedenreich disaccharide linked to threonine within the VTSA motif of MUC1 tandem repeats. Cancer Res. 1995 Sep 15;55(18):4036-40 PMID: 7545084 |
26 | Dahlenborg K, Hultman L, Carlsson R, Jansson B. Human monoclonal antibodies specific for the tumour associated Thomsen-Friedenreich antigen. Int J Cancer. 1997 Jan 6;70(1):63-71 PMID: 8985092 |
27 | Kjeldsen T, Clausen H, Hirohashi S, Ogawa T, Iijima H, Hakomori S. Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res. 1988 Apr 15;48(8):2214-20 PMID: 2450649 |
28 | Karsten U, Butschak G, Cao Y, Goletz S, Hanisch FG. A new monoclonal antibody (A78-G/A7) to the Thomsen-Friedenreich pan-tumor antigen. Hybridoma. 1995 Feb ;14(1):37-44 PMID: 7539400 |
29 | Baldus SE, Zirbes TK, Glossmann J, Fromm S, Hanisch FG, Monig SP, Schroder W, Schneider PM, Flucke U, Karsten U, Thiele J, Holscher AH, Dienes HP. Immunoreactivity of monoclonal antibody BW835 represents a marker of progression and prognosis in early gastric cancer. Oncology. 2001 ;61(2):147-55 PMID: 11528254 |
30 | Schneider F, Kemmner W, Haensch W, Franke G, Gretschel S, Karsten U, Schlag PM. Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomas. Cancer Res. 2001 Jun 1;61(11):4605-11 PMID: 11389097 |
31 | Richter DU, Jeschke U, Makovitzky J, Goletz S, Karsten U, Briese V, Friese K. Expression of the Thomsen-Friedenreich (TF) antigen in the human placenta. Anticancer Res. 2000 Nov ;20(6D):5129-33 PMID: 11326683 |
32 | Baldus SE, Hanisch FG, Monaca E, Karsten UR, Zirbes TK, Thiele J, Dienes HP. Immunoreactivity of Thomsen-Friedenreich (TF) antigen in human neoplasms: the importance of carrier-specific glycotope expression on MUC1. Histol Histopathol. 1999 Oct ;14(4):1153-8 PMID: 10506931 |
33 | Kumar SR, Sauter ER, Quinn TP, Deutscher SL. Thomsen-Friedenreich and Tn antigens in nipple fluid: carbohydrate biomarkers for breast cancer detection. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6868-71 PMID: 16203776 |
34 | Giuffre G, Vitarelli E, Tuccari G, Barresi G. Immunohistochemical study of Tn, sialosyl-Tn and T antigens in human meningiomas. Eur J Histochem. 1998 ;42(3):197-203 PMID: 9857245 |
35 | Ragupathi G, Liu NX, Musselli C, Powell S, Lloyd K, Livingston PO. Antibodies against tumor cell glycolipids and proteins, but not mucins, mediate complement-dependent cytotoxicity. J Immunol. 2005 May 1;174(9):5706-12 PMID: 15843572 |
36 | Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA. Biological significance of cancer-associated sialyl-Tn antigen: Modulation of malignant phenotype in gastric carcinoma cells. Cancer Lett. 2006 Sep 9;[Epub ahead of print]: PMID: 16965854 |
37 | Wu WC, Lai CC, Liu JH, Singh T, Li LM, Peumans WJ, Van Damme EJ, Wu AM. Differential binding to glycotopes among the layers of three mammalian retinal neurons by man-containing N-linked glycan, T(alpha) (Galbeta1-3GalNAcalpha1-), Tn (GalNAcalpha1-Ser/Thr) and I (beta)/II (beta) (Galbeta1-3/4GlcNAcbeta-) reactive lectins. Neurochem Res. 2006 May ;31(5):619-28 PMID: 16770733 |
38 | Rajpert-De Meyts E, Poll SN, Goukasian I, Jeanneau C, Herlihy AS, Bennett EP, Skakkebaek NE, Clausen H, Giwercman A, Mandel U. Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation. Virchows Arch. 2007 Oct ;451(4):805-14 PMID: 17694322 |
39 | Paszkiewicz-Gadek A, Porowska H, Lemancewicz D, Wolczynski S, Gindzienski A. The influence of N- and O-glycosylation inhibitors on the glycosylation profile of cellular membrane proteins and adhesive properties of carcinoma cell lines. Int J Mol Med. 2006 Apr ;17(4):669-74 PMID: 16525726 |
40 | Croce MV, Isla-Larrain M, Rabassa ME, Demichelis S, Colussi AG, Crespo M, Lacunza E, Segal-Eiras A. Lewis x is highly expressed in normal tissues: a comparative immunohistochemical study and literature revision. Pathol Oncol Res. 2007 ;13(2):130-8 PMID: 17607374 |
41 | Singh SK, Streng-Ouwehand I, Litjens M, Weelij DR, García-Vallejo JJ, van Vliet SJ, Saeland E, van Kooyk Y. Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties. Mol Immunol. 2009 Mar ;46(6):1240-9 PMID: 19162326 |
42 | Yoshida H, Fuwa TJ, Arima M, Hamamoto H, Sasaki N, Ichimiya T, Osawa K, Ueda R, Nishihara S. Identification of the Drosophila core 1 beta1,3-galactosyltransferase gene that synthesizes T antigen in the embryonic central nervous system and hemocytes. Glycobiology. 2008 Dec ;18(12):1094-104 PMID: 18824562 |
43 | Kirkeby S, Mikkelsen HB. Distribution of the alphaGal- and the non-alphaGal T-antigens in the pig kidney: potential targets for rejection in pig-to-man xenotransplantation. Immunol Cell Biol. 2008 May ;86(4):363-71 PMID: 18301385 |
44 | Schwientek T, Mandel U, Roth U, Müller S, Hanisch FG. A serial lectin approach to the mucin-type O-glycoproteome of Drosophila melanogaster S2 cells. Proteomics. 2007 Sep ;7(18):3264-77 PMID: 17708590 |
45 | Yu LG. The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression. Glycoconj J. 2007 Nov ;24(8):411-20 PMID: 17457671 |
46 | Wearne KA, Winter HC, Goldstein IJ. Temporal changes in the carbohydrates expressed on BG01 human embryonic stem cells during differentiation as embryoid bodies. Glycoconj J. 2008 Feb ;25(2):121-36 PMID: 17674202 |
47 | Rivinoja A, Kokkonen N, Kellokumpu I, Kellokumpu S. Elevated Golgi pH in breast and colorectal cancer cells correlates with the expression of oncofetal carbohydrate T-antigen. J Cell Physiol. 2006 Jul ;208(1):167-74 PMID: 16547942 |
48 | Argüeso P, Tisdale A, Spurr-Michaud S, Sumiyoshi M, Gipson IK. Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye. Invest Ophthalmol Vis Sci. 2006 Jan ;47(1):113-9 PMID: 16384952 |
49 | Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R. SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen. J Biochem. 2003 Mar ;133(3):271-7 PMID: 12761161 |
50 | Nakamura-Tsuruta S, Kominami J, Kuno A, Hirabayashi J. Evidence that Agaricus bisporus agglutinin (ABA) has dual sugar-binding specificity. Biochem Biophys Res Commun. 2006 Aug 18;347(1):215-20 PMID: 16824489 |
51 | Gaikwad SM, Khan MI. Binding of T-antigen disaccharides to Artocarpus hirsuta lectin and jacalin are energetically different. Photochem Photobiol. 2006 Sep ;82(5):1315-8 PMID: 16776550 |
52 | Kaur N, Dhuna V, Kamboj SS, Agrewala JN, Singh J. A novel antiproliferative and antifungal lectin from Amaranthus viridis Linn seeds. Protein Pept Lett. 2006 ;13(9):897-905 PMID: 17100645 |
53 | Wu AM, Wu JH, Liu JH, Singh T. Recognition profile of Bauhinia purpurea agglutinin (BPA). Life Sci. 2004 Feb 20;74(14):1763-79 PMID: 14741734 |
54 | Singha B, Adhya M, Chatterjee BP. Catfish (Clarias batrachus) serum lectin recognizes polyvalent Tn [alpha-D-GalpNAc1-Ser/Thr], Talpha [beta-D-Galp-(1-->3)-alpha-D-GalpNAc1-Ser/Thr], and II [beta-D-Galp(1-->4)-beta-D-GlcpNAc1-] mammalian glycotopes. Carbohydr Res. 2008 Sep 22;343(14):2384-92 PMID: 18662810 |
55 | Nagae M, Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R. Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition. J Biol Chem. 2006 Nov 24;281(47):35884-93 PMID: 16990264 |
56 | Rhodes JM, Campbell BJ, Yu LG. Lectin-epithelial interactions in the human colon. Biochem Soc Trans. 2008 Dec ;36(Pt 6):1482-6 PMID: 19021580 |
57 | Sangeetha SR, Appukuttan PS. IgA1 is the premier serum glycoprotein recognized by human galectin-1 since T antigen (Galbeta1-->3GalNAc-) is far superior to non-repeating N-acetyl lactosamine as ligand. Int J Biol Macromol. 2005 Jun ;35(5):269-76 PMID: 15862866 |
58 | Lescar J, Sanchez JF, Audfray A, Coll JL, Breton C, Mitchell EP, Imberty A. Structural basis for recognition of breast and colon cancer epitopes Tn antigen and Forssman disaccharide by Helix pomatia lectin. Glycobiology. 2007 Oct ;17(10):1077-83 PMID: 17652409 |
59 | Gowda NM, Goswami U, Khan MI. Purification and characterization of a T-antigen specific lectin from the coelomic fluid of a marine invertebrate, sea cucumber (Holothuria scabra). Fish Shellfish Immunol. 2008 Apr ;24(4):450-8 PMID: 18282768 |
60 | Jeyaprakash AA, Katiyar S, Swaminathan CP, Sekar K, Surolia A, Vijayan M. Structural basis of the carbohydrate specificities of jacalin: an X-ray and modeling study. J Mol Biol. 2003 Sep 5;332(1):217-28 PMID: 12946359 |
61 | Tachibana K, Nakamura S, Wang H, Iwasaki H, Tachibana K, Maebara K, Cheng L, Hirabayashi J, Narimatsu H. Elucidation of binding specificity of Jacalin toward O-glycosylated peptides: quantitative analysis by frontal affinity chromatography. Glycobiology. 2006 Jan ;16(1):46-53 PMID: 16177266 |
62 | Pandey G, Fatma T, Komath SS. Specific interaction of the legume lectins, concanavalin a and peanut agglutinin, with phycocyanin. Photochem Photobiol. 2009 Sep ;85(5):1126-33 PMID: 19496993 |
63 | Wu AM. Polyvalent GalNAcalpha1-->Ser/Thr (Tn) and Galbeta1-->3GalNAcalpha1-->Ser/Thr (T alpha) as the most potent recognition factors involved in Maclura pomifera agglutinin-glycan interactions. J Biomed Sci. 2005 ;12(1):135-52 PMID: 15864746 |
64 | Gilboa-Garber N, Sudakevitz D, Levene C, Rahimi-Levene N, Yahalom V. H-deficient Bombay and para-Bombay red blood cells are most strongly agglutinated by the galactophilic lectins of Aplysia and Pseudomonas aeruginosa that detect I and P1 antigens. Immunohematology. 2006 ;22(1):15-22 PMID: 16563047 |
65 | Natchiar SK, Srinivas O, Mitra N, Surolia A, Jayaraman N, Vijayan M. Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin. Acta Crystallogr D Biol Crystallogr. 2006 Nov ;62(Pt 11):1413-21 PMID: 17057347 |
66 | Chellan B, Narayani J, Appukuttan PS. Galectin-1, an endogenous lectin produced by arterial cells, binds lipoprotein(a) [Lp(a)] in situ: relevance to atherogenesis. Exp Mol Pathol. 2007 Dec ;83(3):399-404 PMID: 17537433 |
67 | Chen L, Sundbäck J, Olofsson S, Jondal M. Interference with O-glycosylation in RMA lymphoma cells leads to a reduced in vivo growth of the tumor. Int J Cancer. 2006 Sep 15;119(6):1495-500 PMID: 16615117 |
68 | Irazoqui FJ, Sendra VG, Lardone RD, Nores GA. Immune response to Thomsen-Friedenreich disaccharide and glycan engineering. Immunol Cell Biol. 2005 Aug ;83(4):405-12 PMID: 16033536 |
69 | Sotiriadis J, Shin SC, Yim D, Sieber D, Kim YB. Thomsen-Friedenreich (T) antigen expression increases sensitivity of natural killer cell lysis of cancer cells. Int J Cancer. 2004 Sep 1;111(3):388-97 PMID: 15221966 |
70 | van Schooten CJ, Denis CV, Lisman T, Eikenboom JC, Leebeek FW, Goudemand J, Fressinaud E, van den Berg HM, de Groot PG, Lenting PJ. Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels. Blood. 2007 Mar 15;109(6):2430-7 PMID: 17090649 |
71 | Huang DT, Chi H, Lee HC, Chiu NC, Huang FY. T-antigen activation for prediction of pneumococcus-induced hemolytic uremic syndrome and hemolytic anemia. Pediatr Infect Dis J. 2006 Jul ;25(7):608-10 PMID: 16804430 |
72 | Wang JS, Lee HC, Huang FY, Chang PY, Sheu JC. Unexpected mortality in pediatric patients with postoperative Hirschsprung's disease. Pediatr Surg Int. 2004 Jul ;20(7):525-8 PMID: 15179519 |
73 | Carrilho C, Cirnes L, Alberto M, Buane L, Mendes N, David L. Distribution of HPV infection and tumour markers in cervical intraepithelial neoplasia from cone biopsies of Mozambican women. J Clin Pathol. 2005 Jan ;58(1):61-8 PMID: 15623485 |
74 | Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA. Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen. Cancer Res. 2004 Oct 1;64(19):7050-7 PMID: 15466199 |
75 | Robertson LA, Moya KL, Breen KC. The potential role of tau protein O-glycosylation in Alzheimer's disease. J Alzheimers Dis. 2004 Oct ;6(5):489-95 PMID: 15505370 |
76 | Persson N, Stuhr-Hansen N, Risinger C, Mereiter S, Polónia A, Polom K, Kovács A, Roviello F, Reis CA, Welinder C, Danielsson L, Jansson B, Blixt O. Epitope mapping of a new anti-Tn antibody detecting gastric cancer cells. Glycobiology. 2017 Jul 1;27:635-645 PMID: 28419225 |
77 | Welinder C, Baldetorp B, Borrebaeck C, Fredlund BM, Jansson B. A new murine IgG1 anti-Tn monoclonal antibody with in vivo anti-tumor activity. Glycobiology. 2011 Aug ;21:1097-107 PMID: 21470982 |